Oxygen transporting ability of lipidheme microspheres as a totally synthetic red cell substitute

Teruyuki Komatsu*, Ayako Kuronuma, Yasuko Muramatsu, Hiroyuki Nishide, Eishun Tsuchida, Toru Kakizaki, Koichi Kobayashi

*この研究の対応する著者

研究成果査読

2 被引用数 (Scopus)

抄録

O2 Binding parameters, O2 solubility and in vivo O2 transporting ability of a lipidheme microsphere as a totally synthetic red cell substitute are described. The O2-binding affinity of the lipidheme microsphere (P1/2(O2): about 40 torr at 37°C) was slightly lower than that of human blood, and its O2 association and dissociation rate constants were larger than those of hemoglobin. The O2 solubility of this solution was estimated; an aqueous solution containing a high amount of dissolved oxygen can be prepared by prescription. The lipidheme microsphere suspension was intravenously injected into hemorrhagic beagles and the circulation lifetime of each constituent of the artificial red cell was determined. The O2 consumption by the lipid-heme was estimated to be about 15% of the total O2 consumption. These results suggest that the lipidheme microsphere has the ability to act as an oxygen carrier in the blood stream.

本文言語English
ページ(範囲)207-215
ページ数9
ジャーナルArtificial Organs Today (Japan)
5
3
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 生体医工学

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