Pain relief associated with decreased oxyhemoglobin level in left dorsolateral prefrontal cortex

Shun Miyashiro, Yurika Yamada, Masaru Nagaoka, Rei Shima, Toshizumi Muta, Haruyuki Ishikawa, Tetsuri Abe, Masashi Hori, Kotaro Oka, Fusako Koshikawa, Etsuro Ito*

*この研究の対応する著者

研究成果: Article査読

抄録

Pain in the elbow, shoulder, knee, lower back, and various other joints is relieved by adhesion of pyramidal thorn patches. To elucidate the pain relief mechanism induced by the patches, we established a quantitative method for estimating the pain reduction and investigated the brain regions that change in association with pain relief. We first attempted to quantify the pain relief using transcutaneous electric stimulation (TCES) and a visual analog scale (VAS), and then applied near-infrared spectroscopy (NIRS) to the prefrontal cortex, including the dorsolateral prefrontal cortex (DLPFC) and the orbitofrontal cortex (OFC). We also examined the salivary oxytocin levels, which are thought to reflect oxytocin secretion levels from the posterior pituitary in the brain. Application of pyramidal thorn patches to pain regions decreased the pain degree estimated using TCES and VAS. Oxyhemoglobin levels were likely to be decreased in the left DLPFC on the basis of NIRS measurements during patch treatment, suggesting that the left DLPFC is involved in pain relief. On the other hand, the salivary oxytocin levels varied widely. A potential reason for the varying salivary oxytocin levels is its utilization in the pain region as an analgesic agent. Our results suggest that the left DLPFC will become a target brain region for pain therapy.

本文言語English
論文番号e0256626
ジャーナルPloS one
16
8 August
DOI
出版ステータスPublished - 2021 8

ASJC Scopus subject areas

  • 一般

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