Paired pulse ratio analysis of insulin-induced synaptic plasticity in the snail brain

Jun Murakami, Ryuichi Okada, Yutaka Fujito, Manabu Sakakibara, Ken Lukowiak, Etsuro Ito

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Insulin's action in the brain can directly alter cognitive functioning. We have recently shown that molluscan insulin-related peptides are upregulated following a conditioned taste aversion (CTA) training procedure. In addition, when mammalian insulin is superfused over the isolated Lymnaea stagnalis central nervous system, it elicits long-term synaptic enhancement at the monosynaptic connection between the cerebral giant cell and the buccal 1 (B1) motor neuron. This synaptic enhancement is thought to be a neural correlate of CTA. Here, we examined whether the observed changes in synaptic plasticity were the result of presynaptic and/or postsynaptic alterations using the paired pulse procedure. The paired pulse ratio was unaltered following insulin application, suggesting that insulin's effects on synaptic plasticity are mediated postsynaptically in the B1 motor neuron. Thus, it was suggested that postsynaptic changes need to be considered when insulin's actions on synaptic plasticity are examined.

本文言語English
ページ(範囲)1771-1773
ページ数3
ジャーナルJournal of Experimental Biology
216
10
DOI
出版ステータスPublished - 2013 5
外部発表はい

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 生理学
  • 水圏科学
  • 動物科学および動物学
  • 分子生物学
  • 昆虫科学

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