PAL31, a nuclear protein required for progression to the S phase

Weiyong Sun, Naka Hattori, Hideki Mutai, Yasushi Toyoshima, Hiromichi Kimura, Satoshi Tanaka, Kunio Shiota

研究成果: Article査読

18 被引用数 (Scopus)


PAL31 is a nuclear protein expressed by various cell types. In the present study, the expression and function of PAL31 were examined in the cytokine-regulated growth of T and B cell lines. Treatment of the cells with mitogens [ovine PRL, recombinant rat placental lactogen-I (PL-I) and human IL-3] caused a dose-dependent increase in the expression of PAL31 mRNA in the PRL-dependent cell line Nb2, and IL-3 dependent cell line BaF3. A time-course study on synchronized Nb2 cells revealed that the expression of PAL31 is specific to the late G1 and S phases. Immunocytological studies revealed that PAL31 accumulates in the nuclei at the S phase. Furthermore, the antisense oligonucleotide for PAL31 severely inhibited the proliferation of Nb2 cells by inhibiting cells progressing to the S phase. Thus, PAL31 is a nuclear protein associated with cell cycle progression.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

フィンガープリント 「PAL31, a nuclear protein required for progression to the S phase」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。