Palladium-catalyzed direct C-H silylation and germanylation of benzamides and carboxamides

Kyalo Stephen Kanyiva, Yoichiro Kuninobu*, Motomu Kanai

*この研究の対応する著者

研究成果: Article査読

93 被引用数 (Scopus)

抄録

A palladium-catalyzed regioselective activation of C(sp2)-H and C(sp3)-H bonds of benzamides and carboxamides, followed by coupling with disilanes to afford organosilanes in moderate to high yields, with the aid of 8-aminoquinoline as a directing group, is reported. Catalytic C(sp 2)-H germanylation of benzamides also proceeds under the same palladium catalysis. The reaction tolerates a wide variety of functional groups and is scalable without yield reduction. The bidentate directing group is readily removed and recovered by the reaction with a hydrazine, with concominant generation of an acyl hydrazide.

本文言語English
ページ(範囲)1968-1971
ページ数4
ジャーナルOrganic Letters
16
7
DOI
出版ステータスPublished - 2014 4 4
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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