抄録
Allylation of carbonucleophiles with allylic carbamates under neutral conditions has been studied. The C-allylation of carbonucleophile is competitive with the N-allylation of amines, and the structure of amines is crucial for the selectivity. Bulky secondary amines gave the best results. Also a new method of protection-deprotection of amines as carbamates has been developed. Smooth deprotection is possible by the palladium-catalyzed reaction of allyl carbamates with formic acid. This method is particulary useful for primary amines, including optically active amino acids.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 2449-2452 |
| ページ数 | 4 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 26 |
| 号 | 20 |
| DOI | |
| 出版ステータス | Published - 1985 |
ASJC Scopus subject areas
- 生化学
- 有機化学
- 創薬