抜粋
Allylation of carbonucleophiles with allylic carbamates under neutral conditions has been studied. The C-allylation of carbonucleophile is competitive with the N-allylation of amines, and the structure of amines is crucial for the selectivity. Bulky secondary amines gave the best results. Also a new method of protection-deprotection of amines as carbamates has been developed. Smooth deprotection is possible by the palladium-catalyzed reaction of allyl carbamates with formic acid. This method is particulary useful for primary amines, including optically active amino acids.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 2449-2452 |
| ページ数 | 4 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 26 |
| 発行部数 | 20 |
| DOI | |
| 出版物ステータス | Published - 1985 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
フィンガープリント Palladium-catalyzed reaction of allyl carbamates; allylation of carbonucleophiles, and protection-deprotection of amines' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Minami, I., Ohashi, Y., Shimizu, I., & Tsuji, J. (1985). Palladium-catalyzed reaction of allyl carbamates; allylation of carbonucleophiles, and protection-deprotection of amines. Tetrahedron Letters, 26(20), 2449-2452. https://doi.org/10.1016/S0040-4039(00)94850-0