抄録
Allylation of carbonucleophiles with allylic carbamates under neutral conditions has been studied. The C-allylation of carbonucleophile is competitive with the N-allylation of amines, and the structure of amines is crucial for the selectivity. Bulky secondary amines gave the best results. Also a new method of protection-deprotection of amines as carbamates has been developed. Smooth deprotection is possible by the palladium-catalyzed reaction of allyl carbamates with formic acid. This method is particulary useful for primary amines, including optically active amino acids.
本文言語 | English |
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ページ(範囲) | 2449-2452 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 26 |
号 | 20 |
DOI | |
出版ステータス | Published - 1985 |
ASJC Scopus subject areas
- 生化学
- 有機化学
- 創薬