Palladium-catalyzed reaction of allyl carbamates; allylation of carbonucleophiles, and protection-deprotection of amines

Ichiro Minami*, Yukihiro Ohashi, Isao Shimizu, Jiro Tsuji

*この研究の対応する著者

    研究成果: Article査読

    88 被引用数 (Scopus)

    抄録

    Allylation of carbonucleophiles with allylic carbamates under neutral conditions has been studied. The C-allylation of carbonucleophile is competitive with the N-allylation of amines, and the structure of amines is crucial for the selectivity. Bulky secondary amines gave the best results. Also a new method of protection-deprotection of amines as carbamates has been developed. Smooth deprotection is possible by the palladium-catalyzed reaction of allyl carbamates with formic acid. This method is particulary useful for primary amines, including optically active amino acids.

    本文言語English
    ページ(範囲)2449-2452
    ページ数4
    ジャーナルTetrahedron Letters
    26
    20
    DOI
    出版ステータスPublished - 1985

    ASJC Scopus subject areas

    • 生化学
    • 有機化学
    • 創薬

    フィンガープリント

    「Palladium-catalyzed reaction of allyl carbamates; allylation of carbonucleophiles, and protection-deprotection of amines」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル