Palladium-Catalyzed sp 3C-H Benzoxylation of Alanine Derivatives Using Aldehydes under Ambient Conditions

Kyalo Stephen Kanyiva*, King Hung Nigel Tang, Jiarui Wang, Takanori Shibata

*この研究の対応する著者

研究成果: Article査読

抄録

The Pd(II)-catalyzed sp 3C-H bond benzoxylation of N -phthaloylalanine derivatives possessing an 8-aminoquinolyl group as a directing group with aldehydes under ambient conditions is reported. When a solution of an alanine derivative and an aldehyde in a toluene/water co-solvent was reacted in the presence of palladium catalyst and tert -butyl hydroperoxide at room temperature, a benzoxylated product was formed in up to 68% yield. The protecting group of the obtained benzoxylated product was smoothly removed to afford a free amide in high yield.

本文言語English
論文番号ss-2021-f0024-st
ジャーナルSynthesis (Germany)
DOI
出版ステータスAccepted/In press - 2021

ASJC Scopus subject areas

  • 触媒
  • 有機化学

フィンガープリント

「Palladium-Catalyzed sp <sup>3</sup>C-H Benzoxylation of Alanine Derivatives Using Aldehydes under Ambient Conditions」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル