Palladium-Catalyzed Tandem Ester Dance/Decarbonylative Coupling Reactions

Masayuki Kubo, Naomi Inayama, Eisuke Ota, Junichiro Yamaguchi

研究成果: Article査読

抄録

"Dance reaction" on the aromatic ring is a powerful method in organic chemistry to translocate functional groups on arene scaffolds. Notably, dance reactions of halides and pseudohalides offer a unique platform for the divergent synthesis of substituted (hetero)aromatic compounds when combined with transition-metal-catalyzed coupling reactions. Herein, we report a tandem reaction of ester dance and decarbonylative coupling enabled by palladium catalysis. In this reaction, 1,2-translocation of the ester moiety on the aromatic ring is followed by decarbonylative coupling with nucleophiles to enable the installation of a variety of nucleophiles at the position adjacent to the ester in the starting material.

本文言語English
ページ(範囲)3855-3860
ページ数6
ジャーナルOrganic Letters
24
21
DOI
出版ステータスPublished - 2022 6月 3

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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