Partial Seeding Policy for Controlling the Crystal Quality in Batch Cooling Crystallization

Joi Unno*, Izumi Hirasawa

*この研究の対応する著者

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Partial seeding, in which the nuclei originating from seed crystals grow to yield the product crystals, was simulated and optimized for controlling the batch cooling crystallization process of L-arginine. The product quality was evaluated by the coefficient of variation (CV) of the crystal size distribution. First, the optimum seed amount for partial seeding was estimated by simulation. Then, the simulated values of the optimum seed amount and the resulting local minimum CV were correlated with the seed crystal size and the cooling rate. The correlation can be utilized for estimating the seed amount in the case that the seed crystals are added in a slurry. Finally, these simulated values were compared to the measured ones. Consequently, the optimum seed amount was suggested to be reasonably predicted.

本文言語English
ページ(範囲)1065-1071
ページ数7
ジャーナルChemical Engineering and Technology
43
6
DOI
出版ステータスPublished - 2020 6月 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)
  • 産業および生産工学

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