Passive distributing method for cellular diagnostic microwell array using self-regulating pinched flow

Kentaro Kawai, Masaki Kanai, Tatsuya Munaka, Hirohisa Abe, Akira Murakami, Shuichi Shoji

研究成果: Paper査読

1 被引用数 (Scopus)

抄録

We developed passive cell distributing method for cellular diagnostic microwell array. This method can distribute cells evenly and simultaneously to a number of microwells only by introducing cell suspensions from the inlet. In order to reduce the dispersion of the number of distributed cells to each microwell, we propose a novel concept of the self-regulating pinched flow. The self-regulating pinched flow is realized in a microchannel, which consists of the center micropillar colonnades and side channels. CFD simulations were carried out to optimize the design of the pinching area. Using a fabricated prototype device having 8 microwells, uniform distribution of the beads was obtained successfully. The coefficient of variation (CV) of the distributed bead in microwells was 29.3%.

本文言語English
ページ500-502
ページ数3
出版ステータスPublished - 2006 1 1
イベント10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
継続期間: 2006 11 52006 11 9

Conference

Conference10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
国/地域Japan
CityTokyo
Period06/11/506/11/9

ASJC Scopus subject areas

  • 化学工学(その他)
  • バイオエンジニアリング

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