Pathophysiological significance of senescence marker protein-30

Naoki Maruyama*, Akihito Ishigami, Yoshitaka Kondo

*この研究の対応する著者

研究成果: Review article査読

36 被引用数 (Scopus)

抄録

A novel rat liver protein of 30 kDa, SMP30 decreases with aging. This protein is expressed most prominently in the liver and kidneys among the various organs. Its gene is located on the X chromosome. No functional domain was recognized in the entire amino acid sequence. Recently, we found a homology between rat SMP30 and two species of bacterial gluconolactonase (EC 3.1.1.17). The lactonase reaction with l-gulono-γ-lactone is the penultimate step in vitamin C (l-ascorbic acid) biosynthesis. SMP30-knockout (KO) mice fed a vitamin C-deficient diet displayed symptoms of scurvy. In SMP30-KO mice, hepatocytes were more susceptible to apoptosis induced by TNF-α plus actinomycin D than hepatocytes from wild-type mice. Two morphological features considered to be a hallmark of senescence are apparent in SMP30-KO mice. At 12 months of age, SMP30-knockout mice had clearly visible deposits of lipofuscin and senescence-associated β-galactosidase (SA-β-GAL) in their renal tubular epithelia. These features are compatible with high electron dense deposits in lysosomes. This observation suggests that the SMP30-knockout mouse is a useful model of ordinal senescence.

本文言語English
ページ(範囲)S88-S98
ジャーナルGeriatrics and Gerontology International
10
SUPPL. 1
DOI
出版ステータスPublished - 2010 7
外部発表はい

ASJC Scopus subject areas

  • 健康(社会科学)
  • 老年学
  • 老年医学

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