PEDOT: gelatin composites mediate brain endothelial cell adhesion

Manuelle Bongo, Orawan Winther-Jensen, Scott Himmelberger, Xenofon Strakosas, Marc Ramuz, Adel Hama, Eleni Stavrinidou, George G. Malliaras, Alberto Salleo*, Bjorn Winther Jensen, Roisin M. Owens

*この研究の対応する著者

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Conducting polymers (CPs) are increasingly being used to interface with cells for applications in both bioelectronics and tissue engineering. To facilitate this interaction, cells need to adhere and grow on the CP surface. Extracellular matrix components are usually necessary to support or enhance cell attachment and growth on polymer substrates. Here we show the preparation of PEDOT(TOS):gelatin composites as a new biocompatible substrate for use in tissue engineering. Gelatin, a derivative of the extracellular matrix protein collagen, was incorporated into poly(3,4 ethylenedioxythiophene)-tosylate (PEDOT(TOS)) films via vapour phase polymerisation (VPP) without changing the electrochemical properties of the CP. Further, gelatin, incorporated into the PEDOT(TOS) film, was found to specifically support bovine brain capillary endothelial cell adhesion and growth, indicating that the functionality of the biomolecule was maintained. The biocompatibility of the composite films was demonstrated indicating the significant future potential of biocomposites of this type for use in promoting cell adhesion in electrically active materials for tissue engineering.

本文言語English
ページ(範囲)3860-3867
ページ数8
ジャーナルJournal of Materials Chemistry B
1
31
DOI
出版ステータスPublished - 2013 8 21
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 生体医工学
  • 医学(全般)
  • 材料科学(全般)

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