Pegylated recombinant human megakaryocyte growth and development factor suppresses the development of megakaryoblastic leukemia in mice

Kazunori Shibuya, Tomoaki Kuwaki, Hiromichi Akahori, Takashi Kato, Hiroshi Miyazaki

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We examined the effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on the development of L-8057, a murine megakaryoblastic leukemia that expresses the thrombopoietin receptor c-Mpl, in mice. PEG-rHuMGDF administration prolonged survival of L-8057 leukemic mice, in which L-8057 cell growth in the spleen was decreased. L-8057 cells harvested from PEG-rHuMGDF-treated leukemic mice had decreased ability to generate leukemic colonies in vitro as well as to induce leukemia in vivo. PEG-rHuMGDF administration also resulted in prolonged survival of mice transplanted with a c-Mpl-expressing erythroleukemia, but had no effect on survival of mice transplanted with a myeloblastic leukemia that does not possess c-Mpl. Thus, PEG-rHuMGDF suppresses the development of c-Mpl-expressing leukemia in vivo in mice.

本文言語English
ページ(範囲)941-946
ページ数6
ジャーナルLeukemia Research
28
9
DOI
出版ステータスPublished - 2004 9 1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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