PEGylated TiO2 nanoparticles mediated inhibition of cell migration via integrin beta 1

Qingqing Sun, Koki Kanehira, Akiyoshi Taniguchi*

*この研究の対応する著者

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Nanoparticles (NPs) elicit various physiological responses in cellular environment, and the effect of NPs on cell migration is of high interest. In this work, the effects of NPs on cell migration and their possible mechanisms were studied. Here, we showed that after exposure to pegylated titanium dioxide nanoparticles (TiO2-PEG NPs, where PEG stands for the polyethylene glycol), NCI-H292 cells exhibited slower migration than control cells. Furthermore, larger NPs inhibited cell migration much stronger than smaller NPs. Following NP exposure, the cells showed decreased expression of integrin beta 1 and phosphorylated focal adhesion kinase (pFAK), and disrupted F-actin structures. We demonstrated that a possible mechanism involved NP-mediated promotion of the lysosomal degradation of integrin beta 1, thus leading to reduced expression of pFAK and cytoskeletal disruption and inhibited cell migration. Therefore, our results showed that inhibition of NCI-H292 cell migration by NPs is mediated through integrin beta 1, which provides useful information for the application of NPs in cancer therapy and related fields.

本文言語English
ページ(範囲)271-281
ページ数11
ジャーナルScience and Technology of Advanced Materials
19
1
DOI
出版ステータスPublished - 2018 12 31
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)

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