Penarolide sulfates A1 and A2, new α-glucosidase inhibitors from a marine sponge Penares sp.

Yoichi Nakao, Takashi Maki, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani

研究成果: Article

32 被引用数 (Scopus)

抄録

Penarolide sulfates A1 (1) and A2 (2) have been isolated as α-glucosidase inhibitors from a marine sponge Penares sp.1 Their structures including absolute stereochemistry were determined to be unique 30- and 31-membered macrolides encompassing a proline residue and three sulfate groups by interpretation of spectral data and chemical degradation. Penarolide sulfates A1 (1) and A2 (2) inhibit α-glucosidase with IC50 values of 1.2 and 1.5 μg/mL, respectively. (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)8977-8987
ページ数11
ジャーナルTetrahedron
56
46
DOI
出版ステータスPublished - 2000 11 10
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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