Peptide-based ligand screening system for g protein-coupled receptors using water-in-oil microdroplets

T. Sakurai, R. Iizuka*, R. Sekine, Y. Nakamura, Donghyun Yoon, Tetsushi Sekiguchi, J. Ishii, A. Kondo, Shuichi Shoji, T. Funatsu

*この研究の対応する著者

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

We present a novel peptide-based ligand screening system for G protein-coupled receptors (GPCRs) in water-in-oil (W/O) microdroplets. This system is an in vitro gene screening system for peptides that activate a target GPCR expressed in yeast. We show that the system is applicable to human GPCRs. This system will be a powerful tool for identifying novel peptide ligands for liganded mammalian GPCRs and orphan mammalian GPCRs.

本文言語English
ホスト出版物のタイトル18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
出版社Chemical and Biological Microsystems Society
ページ965-967
ページ数3
ISBN(印刷版)9780979806476
出版ステータスPublished - 2014
イベント18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
継続期間: 2014 10 262014 10 30

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
国/地域United States
CitySan Antonio
Period14/10/2614/10/30

ASJC Scopus subject areas

  • 制御およびシステム工学

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