Peptide precursors that acquire denatured collagen-hybridizing ability by: O -to- N acyl migration at physiological pH

研究成果: Article

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Here, we report peptide probes with either single or cyclic double stranded collagen-like sequences that spontaneously acquire collagen-hybridizing ability at physiological pH. These peptides have ester bonds derived from O-acyl isopeptide units that are converted to amide bonds via intramolecular O-to-N acyl migration by a pH shift. The peptides that do not require pre-treatment for disassembly will be useful as prodrugs in theranostic treatments targeting unfolded collagen.

元の言語English
ページ(範囲)2823-2827
ページ数5
ジャーナルOrganic and Biomolecular Chemistry
18
発行部数15
DOI
出版物ステータスPublished - 2020 4 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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