Performance evaluation of circadian clocks fluctuated by intrinsic noise

Yohei Ito, Kenko Uchida

    研究成果: Conference contribution

    1 引用 (Scopus)

    抜粋

    Using the linear noise approximation, we approch to the problem of evaluation and prediction of behavior of autonomous oscillatory genetic networks fluctuated by intrinsic noise. In this approach, the state covariance of the networks represents all the information concerning the fluctuation by intrinsic noise, and further, when the genetic network is an autonomous oscillatory system, the state covariance obeys a periodic Lyapunov differential equation that has generally unbounded solutions. Based on the analysis of stability and periodicity properties of the solution to the periodic Lyapunov differential equation, we propose two measures for evaluating intrinsic noise. Circadian clock is a typical example of autonoumous oscillatory genetic networks. Focusing on the simple core model (Gonze and Goldbeter, 2006) for circadian clocks and using the proposed measures, we evaluate robust performances concerning periodicity and amplitude of oscillations in the model fluctuated by intrinsic noise by changing system parameters.

    元の言語English
    ホスト出版物のタイトルProceedings of the IEEE International Conference on Control Applications
    ページ506-511
    ページ数6
    DOI
    出版物ステータスPublished - 2010
    イベント2010 IEEE International Conference on Control Applications, CCA 2010 - Yokohama
    継続期間: 2010 9 82010 9 10

    Other

    Other2010 IEEE International Conference on Control Applications, CCA 2010
    Yokohama
    期間10/9/810/9/10

    ASJC Scopus subject areas

    • Control and Systems Engineering
    • Computer Science Applications
    • Mathematics(all)

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  • これを引用

    Ito, Y., & Uchida, K. (2010). Performance evaluation of circadian clocks fluctuated by intrinsic noise. : Proceedings of the IEEE International Conference on Control Applications (pp. 506-511). [5611315] https://doi.org/10.1109/CCA.2010.5611315