Permeability of anti-fouling PEGylated surfaces probed by fluorescence correlation spectroscopy

Charlisa R. Daniels, Carmen Reznik, Rachel Kilmer, Mary Jane Felipe, Maria Celeste R. Tria, Katerina Kourentzi, Wen Hsiang Chen, Rigoberto C. Advincula, Richard C. Willson, Christy F. Landes*

*この研究の対応する著者

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The present work reports on in situ observations of the interaction of organic dye probe molecules and dye-labeled protein with different poly(ethylene glycol) (PEG) architectures (linear, dendron, and bottle brush). Fluorescence correlation spectroscopy (FCS) and single molecule event analysis were used to examine the nature and extent of probe-PEG interactions. The data support a sieve-like model in which size-exclusion principles determine the extent of probe-PEG interactions. Small probes are trapped by more dense PEG architectures and large probes interact more with less dense PEG surfaces. These results, and the tunable pore structure of the PEG dendrons employed in this work, suggest the viability of electrochemically-active materials for tunable surfaces.

本文言語English
ページ(範囲)31-38
ページ数8
ジャーナルColloids and Surfaces B: Biointerfaces
88
1
DOI
出版ステータスPublished - 2011 11月 1
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

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