We consider SU(2)×U(1) gauge models with an additional global symmetry of Sn type. In particular, we study S4 symmetry for a six-quarksix-lepton standard model. We find that the Kobayashi-Maskawa matrix is completely determined and the mass of the t quark is predicted. Some of the results persist in Sn applied to n families. Restrictions on neutrino masses and mixings are given. Implications of CP and flavor nonconservation that arise in the neutral-Higgs-boson sector are discussed.
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