Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG

Ken Shirato, Kazuhiko Imaizumi, Akihisa Abe, Akio Tomoda*

*この研究の対応する著者

    研究成果: Article査読

    10 被引用数 (Scopus)

    抄録

    The apoptotic effects of 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 2-amino-phenoxazine-3-one (Phx-3) on human glioblastoma cell lines, A-172 and U-251 MG were studied. These phenoxazines extensively decreased the viability of A-172 and U-251 MG cells (IC50 of Phx-1: 60 μM, in both lines; IC50 of Phx-3: 10 and 3 μM, for A-172 and U-251 cells, respectively). Phx-1 and Phx-3 increased the population of annexin V and PI double-positive cells in A-172 and U-251 MG cells, resulting in cell death at late stage apoptosis/necrosis. The activities of caspase-3/7 were greatly increased in A-172 and U-251 MG cells treated with Phx-1 or Phx-3. However, a pan-caspase inhibitor, z-VAD-fmk, failed to reverse the antiproliferative and apoptotic effects of Phx-1 and Phx-3 in both cell lines. In conclusion, Phx-1 and Phx-3 exert significant anti-cancer effects against human glioblastoma cell lines, A-172 and U-251 MG, mediated by the caspase-independent apoptotic cell death pathway.

    本文言語English
    ページ(範囲)201-208
    ページ数8
    ジャーナルOncology Reports
    17
    1
    出版ステータスPublished - 2007 1

    ASJC Scopus subject areas

    • 癌研究
    • 腫瘍学

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