Phosphorylated gelatin to enhance cell adhesion to titanium

Shin Hye Park, Liping Zhu, Seiichi Tada, Sei Obuse, Yasuhiro Yoshida, Mariko Nakamura, Tae Il Son, Satoshi Tsuneda, Yoshihiro Ito*

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Phosphorylated gelatin was prepared for surface modification of titanium to enhance cell attachment. The modified gelatin was synthesized by coupling gelatin with phosphonobutyric acid with water-soluble carbodiimide. Circular dichroism revealed no significant change in the gelatin as a result of phosphorylation. The binding behavior of phosphorylated gelatin on the titanium surface was observed by quartz crystal microbalance. The modified titanium surface was analyzed by measuring the water contact angle. Enhancement of the attachment of osteoblast cells MC-3T3L1 was observed on the phosphorylated-gelatin-modified titanium. Phosphorylation of gelatin was effective for preparation of a cell-adhesive titanium surface.

本文言語English
ページ(範囲)1616-1619
ページ数4
ジャーナルPolymer International
63
9
DOI
出版ステータスPublished - 2014 9

ASJC Scopus subject areas

  • ポリマーおよびプラスチック
  • 有機化学
  • 材料化学

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