Photoactivatable Substrates: A Material-Based Approach for Dissecting Cell Migration

Jun Nakanishi*

*この研究の対応する著者

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Photoactivatable substrates, which show changes in surface cell adhesiveness in response to photoirradiation, are promising platforms for cell manipulation with high spatiotemporal resolution. In addition to having applications in cell and tissue engineering, these materials are unique tools for basic biological sciences research, and they complement conventional genetic engineering technologies. One of the most useful applications is in the study of cell migration, which occurs in various physiological and pathological processes. In this personal account, I provide a brief overview of the development of photoactivatable substrates and their applications, highlighting in particular the contributions of our research group to collective cell migration studies. This material-based approach is useful for dissecting the molecular biological and mechanobiological aspects of the regulatory mechanisms in the cellular social activities.

本文言語English
ページ(範囲)611-621
ページ数11
ジャーナルChemical Record
17
6
DOI
出版ステータスPublished - 2017 6月 1
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 生化学
  • 化学工学(全般)
  • 材料化学

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