Photoreception and circadian clock system of the chicken pineal gland

Toshiyuki Okano, Yoshitaka Fukada*


研究成果: Review article査読

34 被引用数 (Scopus)


Chicken pinealocytes contain three major components of the circadian clock system: 1) a self-sustained oscillator, 2) a photic-input pathway to the oscillator, and 3) an overt output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input-oscillator-output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal-specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription/translation-based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN.

ジャーナルMicroscopy Research and Technique
出版ステータスPublished - 2001 4月 1

ASJC Scopus subject areas

  • 解剖学
  • 組織学
  • 器械工学
  • 医療検査技術


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