Physical Training Protects Against Brain Toxicity in Mice Exposed to an Experimental Model of Glioblastoma

Amanda K. Costa, Luis F.B. Marqueze, Bruna B. Gattiboni, Giulia S. Pedroso, Franciane F. Vasconcellos, Eduardo B.B. Cunha, Hanna C. Justa, Antonielle B. Baldissera, Seigo Nagashima, Lucia de Noronha, Zsolt Radak, Luiz C. Fernandes, Ricardo A. Pinho*

*この研究の対応する著者

研究成果: Article査読

抄録

Glioma 261 (Gl261) cell-mediated neurotoxicity has been reported in previous studies examining glioblastoma (GBM), and the effects of physical exercise (PE) on this neurotoxicity have been poorly investigated. This study aimed to evaluate the effects of a PE program in animals with experimental GBM. Male C57BL/6J mice were randomized into sham or GBM groups and subjected to a PE program for four weeks. Gl261 cells were administered into the intraventricular region at 48 h after the last exercise session. Body weight, water and feed consumption, and behavior were all evaluated for 21 days followed by euthanasia. The right parietal lobe was removed for the analysis of glial fibrillary acidic protein (GFAP), epidermal growth factor receptor (EGFR), vimentin, C-myc, nuclear factor kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), hydrogen peroxide, the glutathione system, and oxidative damage to proteins. The results revealed changes in the behavioral patterns of the trained animals, and no anatomopathological changes were observed in response to PE training. In contrast, animals with GBM subjected to PE exhibited lower immunoexpression of c-MYC, vimentin, and GFAP. Although experimental GBM altered the redox profile and inflammatory mediators, no significant alterations were observed after PE. In conclusion, our data provide consistent evidence of the relationship between PE and the improvement of tumorigenic parameters against the neurotoxicity of GL261 cells.

本文言語English
ページ(範囲)3344-3354
ページ数11
ジャーナルNeurochemical Research
47
11
DOI
出版ステータスPublished - 2022 11月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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