Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida

研究成果: Paper

抜粋

Hb-vesicles (HbV) are artificial O2 carriers as a transfusion alternative. We examined the physiological capacity for the degradation of HbV by daily repeated infusions (DRI). Male Wistar rats intravenously received the HbV at 10 mL/kg/day for 14 consecutive days. One day after DRI, hepatosplenomegaly occurred significantly through the accumulation of large amounts of HbV. Plasma clinical chemistry was overall normal, except for a transient elevation of lipid components derived from HbV. These symptoms subsided 14 days after DRI. The plasma iron and bilirubin levels remained unchanged, suggesting that the heme-degrading capacity of the RES did not surpass the ability to eliminate bilirubin. Accordingly, Hb encapsulation would be beneficial for heme detoxification through their preferential delivery to the RES, a physiologic compartment for degradation of senescent RBCs, even at doses greater than putative clinical doses.

元の言語English
ページ数1
出版物ステータスPublished - 2005 12 1
イベント54th SPSJ Annual Meeting 2005 - Yokohama, Japan
継続期間: 2005 5 252005 5 27

Conference

Conference54th SPSJ Annual Meeting 2005
Japan
Yokohama
期間05/5/2505/5/27

    フィンガープリント

ASJC Scopus subject areas

  • Engineering(all)

これを引用

Sakai, H., Sou, K., Takeoka, S., Horinouchi, H., Kobayashi, K., & Tsuchida, E. (2005). Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days. 論文発表場所 54th SPSJ Annual Meeting 2005, Yokohama, Japan.