Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida

    研究成果: Conference contribution

    抄録

    Hb-vesicles (HbV) are artificial O2 carriers as a transfusion alternative. We examined the physiological capacity for the degradation of HbV by daily repeated infusions (DRI). Male Wistar rats intravenously received the HbV at 10 mL/kg/day for 14 consecutive days. One day after DRI, hepatosplenomegaly occurred significantly through the accumulation of large amounts of HbV. Plasma clinical chemistry was overall normal, except for a transient elevation of lipid components derived from HbV. These symptoms subsided 14 days after DRI. The plasma iron and bilirubin levels remained unchanged, suggesting that the heme-degrading capacity of the RES did not surpass the ability to eliminate bilirubin. Accordingly, Hb encapsulation would be beneficial for heme detoxification through their preferential delivery to the RES, a physiologic compartment for degradation of senescent RBCs, even at doses greater than putative clinical doses.

    元の言語English
    ホスト出版物のタイトルPolymer Preprints, Japan
    ページ2272
    ページ数1
    54
    エディション1
    出版物ステータスPublished - 2005
    イベント54th SPSJ Annual Meeting 2005 - Yokohama
    継続期間: 2005 5 252005 5 27

    Other

    Other54th SPSJ Annual Meeting 2005
    Yokohama
    期間05/5/2505/5/27

    Fingerprint

    Plasmas
    Degradation
    Detoxification
    Oxygen
    Encapsulation
    Lipids
    Rats
    Iron
    Clinical Chemistry

    ASJC Scopus subject areas

    • Engineering(all)

    これを引用

    Sakai, H., Sou, K., Takeoka, S., Horinouchi, H., Kobayashi, K., & Tsuchida, E. (2005). Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days. : Polymer Preprints, Japan (1 版, 巻 54, pp. 2272)

    Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days. / Sakai, Hiromi; Sou, Keitaro; Takeoka, Shinji; Horinouchi, Hirohisa; Kobayashi, Koichi; Tsuchida, Eishun.

    Polymer Preprints, Japan. 巻 54 1. 編 2005. p. 2272.

    研究成果: Conference contribution

    Sakai, H, Sou, K, Takeoka, S, Horinouchi, H, Kobayashi, K & Tsuchida, E 2005, Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days. : Polymer Preprints, Japan. 1 Edn, 巻. 54, pp. 2272, 54th SPSJ Annual Meeting 2005, Yokohama, 05/5/25.
    Sakai, Hiromi ; Sou, Keitaro ; Takeoka, Shinji ; Horinouchi, Hirohisa ; Kobayashi, Koichi ; Tsuchida, Eishun. / Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days. Polymer Preprints, Japan. 巻 54 1. 版 2005. pp. 2272
    @inproceedings{63264296d79c465195b66dfd97c8c539,
    title = "Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days",
    abstract = "Hb-vesicles (HbV) are artificial O2 carriers as a transfusion alternative. We examined the physiological capacity for the degradation of HbV by daily repeated infusions (DRI). Male Wistar rats intravenously received the HbV at 10 mL/kg/day for 14 consecutive days. One day after DRI, hepatosplenomegaly occurred significantly through the accumulation of large amounts of HbV. Plasma clinical chemistry was overall normal, except for a transient elevation of lipid components derived from HbV. These symptoms subsided 14 days after DRI. The plasma iron and bilirubin levels remained unchanged, suggesting that the heme-degrading capacity of the RES did not surpass the ability to eliminate bilirubin. Accordingly, Hb encapsulation would be beneficial for heme detoxification through their preferential delivery to the RES, a physiologic compartment for degradation of senescent RBCs, even at doses greater than putative clinical doses.",
    keywords = "Artificial red cells, Daily repeated infusion, Heme-detoxification, Liposome, MPS, RES",
    author = "Hiromi Sakai and Keitaro Sou and Shinji Takeoka and Hirohisa Horinouchi and Koichi Kobayashi and Eishun Tsuchida",
    year = "2005",
    language = "English",
    volume = "54",
    pages = "2272",
    booktitle = "Polymer Preprints, Japan",
    edition = "1",

    }

    TY - GEN

    T1 - Physiologic capacity of reticuloendothelial system for degradation of Hb-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

    AU - Sakai, Hiromi

    AU - Sou, Keitaro

    AU - Takeoka, Shinji

    AU - Horinouchi, Hirohisa

    AU - Kobayashi, Koichi

    AU - Tsuchida, Eishun

    PY - 2005

    Y1 - 2005

    N2 - Hb-vesicles (HbV) are artificial O2 carriers as a transfusion alternative. We examined the physiological capacity for the degradation of HbV by daily repeated infusions (DRI). Male Wistar rats intravenously received the HbV at 10 mL/kg/day for 14 consecutive days. One day after DRI, hepatosplenomegaly occurred significantly through the accumulation of large amounts of HbV. Plasma clinical chemistry was overall normal, except for a transient elevation of lipid components derived from HbV. These symptoms subsided 14 days after DRI. The plasma iron and bilirubin levels remained unchanged, suggesting that the heme-degrading capacity of the RES did not surpass the ability to eliminate bilirubin. Accordingly, Hb encapsulation would be beneficial for heme detoxification through their preferential delivery to the RES, a physiologic compartment for degradation of senescent RBCs, even at doses greater than putative clinical doses.

    AB - Hb-vesicles (HbV) are artificial O2 carriers as a transfusion alternative. We examined the physiological capacity for the degradation of HbV by daily repeated infusions (DRI). Male Wistar rats intravenously received the HbV at 10 mL/kg/day for 14 consecutive days. One day after DRI, hepatosplenomegaly occurred significantly through the accumulation of large amounts of HbV. Plasma clinical chemistry was overall normal, except for a transient elevation of lipid components derived from HbV. These symptoms subsided 14 days after DRI. The plasma iron and bilirubin levels remained unchanged, suggesting that the heme-degrading capacity of the RES did not surpass the ability to eliminate bilirubin. Accordingly, Hb encapsulation would be beneficial for heme detoxification through their preferential delivery to the RES, a physiologic compartment for degradation of senescent RBCs, even at doses greater than putative clinical doses.

    KW - Artificial red cells

    KW - Daily repeated infusion

    KW - Heme-detoxification

    KW - Liposome

    KW - MPS

    KW - RES

    UR - http://www.scopus.com/inward/record.url?scp=33645638711&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=33645638711&partnerID=8YFLogxK

    M3 - Conference contribution

    AN - SCOPUS:33645638711

    VL - 54

    SP - 2272

    BT - Polymer Preprints, Japan

    ER -