Piceatannol is superior to resveratrol in promoting neural stem cell differentiation into astrocytes

Daisuke Arai, Ryousuke Kataoka, Satoshi Otsuka, Midori Kawamura, Hiroko Maruki-Uchida, Masahiko Sai, Tatsuhiko Ito, Yoichi Nakao

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Piceatannol (3,3′,4′,5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3,4′,5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol. At a concentration of 2.5 μM, piceatannol promoted astrocyte differentiation, while resveratrol had no effect at this concentration. Furthermore, we found that oral administration of piceatannol increased the number of astrocytes in the brains of adult mice, while resveratrol administration showed no effects. These results suggest that piceatannol has a superior effect to resveratrol in promoting astrocyte differentiation.

本文言語English
ページ(範囲)4432-4441
ページ数10
ジャーナルFood and Function
7
10
DOI
出版ステータスPublished - 2016 10

ASJC Scopus subject areas

  • 食品科学

フィンガープリント

「Piceatannol is superior to resveratrol in promoting neural stem cell differentiation into astrocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル