Piezoelectric allostery of protein

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    Allostery is indispensable for a protein to work, where a locally applied stimulus is transmitted to a distant part of the molecule. While the allostery due to chemical stimuli such as ligand binding has long been studied, the growing interest in mechanobiology prompts the study of the mechanically stimulated allostery, the physical mechanism of which has not been established. By molecular dynamics simulation of a motor protein myosin, we found that a locally applied mechanical stimulus induces electrostatic potential change at distant regions, just like the piezoelectricity. This novel allosteric mechanism, "piezoelectric allostery", should be of particularly high value for mechanosensor/transducer proteins.

    元の言語English
    記事番号012406
    ジャーナルPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
    94
    発行部数1
    DOI
    出版物ステータスPublished - 2016 7 13

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    ASJC Scopus subject areas

    • Condensed Matter Physics
    • Statistical and Nonlinear Physics
    • Statistics and Probability

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