Piezoelectric allostery of protein

Jun Ohnuki, Takato Sato, Mitsunori Takano*

*この研究の対応する著者

研究成果査読

8 被引用数 (Scopus)

抄録

Allostery is indispensable for a protein to work, where a locally applied stimulus is transmitted to a distant part of the molecule. While the allostery due to chemical stimuli such as ligand binding has long been studied, the growing interest in mechanobiology prompts the study of the mechanically stimulated allostery, the physical mechanism of which has not been established. By molecular dynamics simulation of a motor protein myosin, we found that a locally applied mechanical stimulus induces electrostatic potential change at distant regions, just like the piezoelectricity. This novel allosteric mechanism, "piezoelectric allostery", should be of particularly high value for mechanosensor/transducer proteins.

本文言語English
論文番号012406
ジャーナルPhysical Review E
94
1
DOI
出版ステータスPublished - 2016 7 13

ASJC Scopus subject areas

  • 統計物理学および非線形物理学
  • 統計学および確率
  • 凝縮系物理学

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