Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation

Attilio Marino*, Satoshi Arai, Yanyan Hou, Edoardo Sinibaldi, Mario Pellegrino, Young Tae Chang, Barbara Mazzolai, Virgilio Mattoli, Madoka Suzuki, Gianni Ciofani

*この研究の対応する著者

研究成果: Article査読

167 被引用数 (Scopus)

抄録

Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.

本文言語English
ページ(範囲)7678-7689
ページ数12
ジャーナルACS Nano
9
7
DOI
出版ステータスPublished - 2015 7月 28

ASJC Scopus subject areas

  • 工学(全般)
  • 材料科学(全般)
  • 物理学および天文学(全般)

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