Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis

Satoshi Yoshida, Keiko Kono, Drew M. Lowery, Sara Bartolini, Michael B. Yaffe, Yoshikazu Ohya, David Pellman

研究成果: Article査読

119 被引用数 (Scopus)

抄録

The links between the cell cycle machinery and the cytoskeletal proteins controlling cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP)-binding protein RhoA stimulates type II myosin contractility and formin-dependent assembly of the cytokinetic actin contractile ring. We found that budding yeast Polo-like kinase Cdc5 controls the targeting and activation of Rho1 (RhoA) at the division site via Rho1 guanine nucleotide exchange factors. This role of Cdc5 (Polo-like kinase) in regulating Rho1 is likely to be relevant to cytokinesis and asymmetric cell division in other organisms.

本文言語English
ページ(範囲)108-111
ページ数4
ジャーナルScience
313
5783
DOI
出版ステータスPublished - 2006 7 7
外部発表はい

ASJC Scopus subject areas

  • 一般

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