Polymorph Control of L-Phenylalanine in Cooling Crystallization by Ultrasonication

    研究成果: Article

    2 引用 (Scopus)

    抄録

    Most of the amino acids that are utilized as medical raw materials and food additives show polymorphism. To improve the physical and chemical properties of the crystals, an effective method for polymorph control is required in the crystallization process. In this study, polymorph control of L-phenylalanine in cooling crystallization by ultrasonication was investigated. L-Phenylalanine crystallizes in anhydrate and monohydrate forms. Without ultrasonication, a mixture of monohydrate and anhydrate forms was obtained. In contrast, the yield of monohydrate was increased by ultrasonication. In addition, ultrasonication shortened the induction time. It was considered that ultrasonic energy could supply the energy required for primary nucleation.

    元の言語English
    ジャーナルChemical Engineering and Technology
    DOI
    出版物ステータスAccepted/In press - 2018 1 1

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    Crystallization
    Polymorphism
    Phenylalanine
    Cooling
    Food additives
    Chemical properties
    Amino acids
    Raw materials
    Nucleation
    Physical properties
    Ultrasonics
    Amino Acids
    Crystals

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)
    • Industrial and Manufacturing Engineering

    これを引用

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    abstract = "Most of the amino acids that are utilized as medical raw materials and food additives show polymorphism. To improve the physical and chemical properties of the crystals, an effective method for polymorph control is required in the crystallization process. In this study, polymorph control of L-phenylalanine in cooling crystallization by ultrasonication was investigated. L-Phenylalanine crystallizes in anhydrate and monohydrate forms. Without ultrasonication, a mixture of monohydrate and anhydrate forms was obtained. In contrast, the yield of monohydrate was increased by ultrasonication. In addition, ultrasonication shortened the induction time. It was considered that ultrasonic energy could supply the energy required for primary nucleation.",
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    KW - Polymorphism

    KW - Sonocrystallization

    KW - Ultrasound

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