Population genetics of non-genetic traits: Evolutionary roles of stochasticity in gene expression

Katsuhiko Mineta, Tomotaka Matsumoto, Naoki Osada, Hitoshi Araki*

*この研究の対応する著者

研究成果: Review article査読

12 被引用数 (Scopus)

抄録

The role of stochasticity in evolutionary genetics has long been debated. To date, however, the potential roles of non-genetic traits in evolutionary processes have been largely neglected. In molecular biology, growing evidence suggests that stochasticity in gene expression (SGE) is common and that SGE has major impacts on phenotypes and fitness. Here, we provide a general overview of the potential effects of SGE on population genetic parameters, arguing that SGE can indeed have a profound effect on evolutionary processes. Our analyses suggest that SGE potentially alters the fate of mutations by influencing effective population size and fixation probability. In addition, a genetic control of SGE magnitude could evolve under certain conditions, if the fitness of the less-fit individual increases due to SGE and environmental fluctuation. Although empirical evidence for our arguments is yet to come, methodological developments for precisely measuring SGE in living organisms will further advance our understanding of SGE-driven evolution.

本文言語English
ページ(範囲)16-21
ページ数6
ジャーナルGene
562
1
DOI
出版ステータスPublished - 2015 5月 10
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

フィンガープリント

「Population genetics of non-genetic traits: Evolutionary roles of stochasticity in gene expression」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル