Porphyrins and porphines inhibit the ribonuclease P reaction in vitro.

Yoshiaki Hori*, Elena V. Bichenkova, Amanda N. Wilton, Terumichi Tanaka, Kenneth T. Douglas, Yo Kikuchi

*この研究の対応する著者

研究成果: Chapter

3 被引用数 (Scopus)

抄録

Porphyrin has been reported to bind to the T psi C stem of tRNA. This site is also recognized by ribonuclease P, which is essential and ubiquitous endoribonuclease responsible for the maturation of 5' ends of tRNA precursors. Thus, we investigated the effects of porphyrins on the in vitro reaction of ribonuclease P from Escherichia coli. The results showed that some of porphyrins inhibited the reaction more strongly than any other inhibitors reported so far. In addition to the benzimidazole inhibition that we have previously reported, these unusual substrate-binding inhibitions may provide new leads for the novel anti-bacterial reagent design.

本文言語English
ホスト出版物のタイトルNucleic acids research. Supplement (2001)
ページ111-112
ページ数2
2
出版ステータスPublished - 2002
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