Potential role of lipin-1 in exercise-induced mitochondrial biogenesis

Kazuhiko Higashida, Mitsuru Higuchi, Shin Terada*

*この研究の対応する著者

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Endurance exercise induces mitochondrial biogenesis in skeletal muscle. It has been shown that lipin-1 acts as a transcriptional coactivator in liver, and stimulates gene expression of mitochondrial enzymes. We hypothesized that lipin-1 might be involved in exercise-induced mitochondrial biogenesis in skeletal muscle. The present investigation first demonstrated that lipin-1 mRNA in rat triceps muscle was increased by approximately 2-fold after an acute bout of endurance swimming exercise. Second, ectopic expression of lipin-1 in L6 myotube increased carnitine palmitoyltransferase-1 and δ-aminolevulinate synthase gene expression. Finally, lipin-1 mRNA expression in rat triceps muscle was significantly elevated at 6 h after subcutaneous injections of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or clenbuterol, which are 5′-AMP-activated protein kinase (AMPK) and β2-adrenergic receptor (β2-AR) activators, respectively. These results may suggest that enhanced expression of lipin-1 is involved in exercise-induced mitochondrial enzyme adaptations, possibly through AMPK- and β2-AR-related mechanisms.

本文言語English
ページ(範囲)587-591
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
374
3
DOI
出版ステータスPublished - 2008 9月 26

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 分子生物学

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