Potentiometric detection of serotonin, melatonin, and their precursors/metabolites with monolayer-modified indium tin oxide electrode and their concentration dependency

Zaved Hossain Khan, Takuya Nakanishi, Tetsuya Osaka*

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

A novel potentiometric method using an indium tin oxide (ITO) electrode, surface-treated with aminopropylsilane and disuccinimidyl suberate successively, has been developed for measuring serotonin (5-HT), 5-hydroxy-L-tryptophan (5-HTP), 5-hydroxy-indole-acetic acid (5-HIAA), and melatonin (MT) (N-acetyl-5-methoxytryptamine) in phosphate buffered saline (PBS) solution (pH 7.4). A linear concentration range of 1 nM to 100 μM was obtained with a correlation coefficient of 0.995 for all target analytes. The minimum detectable concentration obtained was 0.1 nM for 5-HT and 1.0 nM for other analytes. The relationship between the molecular structure of the indole derivatives and the enhanced potential shift behaviour was also discussed. This simple and efficient method can be used to measure other neurotransmitters, as well.

本文言語English
ページ(範囲)1849-1852
ページ数4
ジャーナルSensor Letters
9
5
DOI
出版ステータスPublished - 2011 10月

ASJC Scopus subject areas

  • 原子分子物理学および光学
  • 電子工学および電気工学

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