Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Shunsuke Inenaga; Keitaro Sou; Shinji Takeoka; Eishun Tsuchida

Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Shunsuke Inenaga, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

先進理工学部

研究成果: Paper › 査読

抄録

The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

本文言語	English
ページ数	1
出版ステータス	Published - 2006 12 1
イベント	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan 継続期間: 2006 9 20 → 2006 9 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country	Japan
City	Toyama
Period	06/9/20 → 06/9/22

ASJC Scopus subject areas

Engineering(all)

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引用スタイル

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abstract = "The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.",

keywords = "Anionio lipid, Curcumin, Drug delivery, Emulsion, Lipophilic drug, Pharmacokinetics",

author = "Shunsuke Inenaga and Keitaro Sou and Shinji Takeoka and Eishun Tsuchida",

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T1 - Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

AU - Inenaga, Shunsuke

AU - Sou, Keitaro

AU - Takeoka, Shinji

AU - Tsuchida, Eishun

PY - 2006/12/1

Y1 - 2006/12/1

N2 - The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

AB - The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

KW - Anionio lipid

KW - Curcumin

KW - Drug delivery

KW - Emulsion

KW - Lipophilic drug

KW - Pharmacokinetics

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M3 - Paper

AN - SCOPUS:33846127856

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -