Preparation of a Chiral Building Block by an Organocatalytic Asymmetric Intramolecular Michael Reaction

Yusuke Sato, Yosuke Hosoya, Ikumi Kobayashi, Kyohei Adachi, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The preparation of a chiral building block, including a stereodiad consisting of two tertiary stereogenic centers, by a highly enantioselective organocatalytic intramolecular Michael reaction is described. The use of a chiral secondary-amine-bearing thiourea substituted with a para-nitrophenyl group in the presence of benzoic acid is key to preparing the chiral building block in high yield and excellent enantioselectivity. The prepared chiral building block has both aldehyde and nitro groups, allowing a variety of functional-group transformations necessary for the total synthesis of atisane-type terpenoids.

本文言語English
ページ(範囲)1033-1036
ページ数4
ジャーナルAsian Journal of Organic Chemistry
8
7
DOI
出版ステータスPublished - 2019 7月

ASJC Scopus subject areas

  • 有機化学

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