Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai, Ryouta Araki, Kazue Hiraka, Shoichiro Asayama, Shoji Nagaoka, Tomomi Hatsugai, Akihiko Ogata, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

研究成果: Paper査読

抄録

We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

本文言語English
ページ数1
出版ステータスPublished - 2005 12 1
外部発表はい
イベント54th SPSJ Annual Meeting 2005 - Yokohama, Japan
継続期間: 2005 5 252005 5 27

Conference

Conference54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

ASJC Scopus subject areas

  • Engineering(all)

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