Preparation of novel synthons, uniquely functionalized tetrahydrofuran and tetrahydropyran derivatives

Masahisa Nakada, Masashi Takano, Yukitaka Iwata

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The dianion of the acetoacetic ester reacts with epibromohydrin derivatives to afford a mixture of (Z)-2-alkoxycarbonylmethylidenetetrahydrofuran derivative and (E)-2-alkoxycarbonylmethylidenetetrahydropyran derivative. The selective formation of the tetrahydrofuran derivative is achieved by the use of LiCIO4 as the additive. The preparation of the optically active tetrahydrofuran derivatives and tetrahydropyran derivatives is also examined, and the optical purity and absolute configuration of the products is elucidated.

本文言語English
ページ(範囲)1581-1585
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
48
10
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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