Preparation of pH-sensitive liposomes retaining SOD mimic and their anticancer effect

Kazue Hiraka, Mayuko Kanehisa, Miho Tamai, Shoichiro Asayama, Shoji Nagaoka, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami*

*この研究の対応する著者

研究成果: Article査読

30 被引用数 (Scopus)

抄録

We prepared an anticancer drug based on a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic. The liposomes contained cationic/anionic lipid combinations and were composed of Fe-porphyrin, 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine, dimethylditetradecylammonium bromide, sodium oleate, and Tween-80. The Fe-porphyrin was released from the liposome at low pH, and the cytotoxicity for cancer cells by the liposome depended on the acidic environments of the endosomes in the cells. Furthermore, although the liposome exhibited an excellent anticancer effect on a gastric cancer cell line, the SOD activity of Fe-porphyrin was shown to have a significant influence on the cytotoxicity toward cancer cells. These findings suggest that the pH-sensitive liposome retaining the Fe-porphyrin as an SOD mimic promises to be a novel anticancer drug for endosomal escape.

本文言語English
ページ(範囲)54-58
ページ数5
ジャーナルColloids and Surfaces B: Biointerfaces
67
1
DOI
出版ステータスPublished - 2008 11 15
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

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