Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice

Tomio Narisawa, Yoko Fukaura, Kunihiko Terada, Akiko Umezawa*, Noritoshi Tanida, Kazunaga Yazawa, Chikako Ishikawa

*この研究の対応する著者

研究成果: Article査読

79 被引用数 (Scopus)

抄録

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.005 and 0.001% levels in drinking water, and Si at 0.01 and 0.002% levels in the diet. All animals had access to Pr or Si throughout the experiments which were terminated at weeks 25 or 30. Histologically most of the tumors were well-differentiated adenocarcinomas. The incidence of colon tumors examined at weeks 25 or 30 was reduced by 67% in the 0.01% Pr group, by 30% in the 0.005% Pr and 0.01% Si groups, and by 24% in the 0.001% Pr and 0.002% Si groups, compared with their respective controls. However, the differences did not reach statistical significance. The number of tumors per mouse was significantly reduced in all groups administered Pr and Si except the 0.001% Pr group as compared to their respective controls. The results from those three independent experiments seem to suggest that HMG-CoA reductase inhibitors may prevent colon tumorigenesis in laboratory animal model.

本文言語English
ページ(範囲)2045-2048
ページ数4
ジャーナルCarcinogenesis
15
9
出版ステータスPublished - 1994 9
外部発表はい

ASJC Scopus subject areas

  • 癌研究
  • 統計学、確率および不確実性
  • 応用数学
  • 生理学(医学)
  • 生理学
  • 行動神経科学

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