Principal component analysis of odor coding at the level of third-order olfactory neurons in Drosophila

Makoto Hiroi, Masamichi Ohkura, Junichi Nakai, Naoki Masuda, Koichi Hashimoto, Kiichi Inoue, André Fiala, Tetsuya Tabata*

*この研究の対応する著者

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Olfactory information in Drosophila is conveyed by projection neurons from olfactory sensory neurons to Kenyon cells (KCs) in the mushroom body (MB). A subset of KCs responds to a given odor molecule, and the combination of these KCs represents a part of the neuronal olfactory code. KCs are also thought to function as coincidence detectors for memory formation, associating odor information with a coincident punishment or reward stimulus. Associative conditioning has been shown to modify KC output. This plasticity occurs in the vertical lobes of MBs containing α/α' branches of KCs, which is shown by measuring the average Ca2+ levels in the branch of each lobe. We devised a method to quantitatively describe the population activity patterns recorded from axons of >1000 KCs at the α/α' branches using two-photon Ca2+ imaging. Principal component analysis of the population activity patterns clearly differentiated the responses to distinct odors.

本文言語English
ページ(範囲)1070-1081
ページ数12
ジャーナルGenes to Cells
18
12
DOI
出版ステータスPublished - 2013 12
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 細胞生物学

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