抄録
We have developed a mouse transgenesis technique that facilitates the insertion of large (∼200 kilo base pairs) DNA fragments into host genomes of both inbred and hybrid mice. Six inbred and three hybrid transgenic mice carrying a single bacterial artificial chromosome (BAC) clone with genes located in the Down syndrome critical region of human chromosome 21 were produced using this technology.
本文言語 | English |
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ページ(範囲) | 329-335 |
ページ数 | 7 |
ジャーナル | Molecular Reproduction and Development |
巻 | 72 |
号 | 3 |
DOI | |
出版ステータス | Published - 2005 11月 |
外部発表 | はい |
ASJC Scopus subject areas
- 遺伝学
- 発生生物学
- 細胞生物学