Production of inbred and hybrid transgenic mice carrying large (>200 kb) foreign DNA fragments by intracytoplasmic sperm injection

Tomoharu Osada*, Atsushi Toyoda, Stefan Moisyadi, Hidenori Akutsu, Masahira Hattori, Yoshiyuio Sakaki, Ryuzo Yanagimachi

*この研究の対応する著者

研究成果: Article査読

27 被引用数 (Scopus)

抄録

We have developed a mouse transgenesis technique that facilitates the insertion of large (∼200 kilo base pairs) DNA fragments into host genomes of both inbred and hybrid mice. Six inbred and three hybrid transgenic mice carrying a single bacterial artificial chromosome (BAC) clone with genes located in the Down syndrome critical region of human chromosome 21 were produced using this technology.

本文言語English
ページ(範囲)329-335
ページ数7
ジャーナルMolecular Reproduction and Development
72
3
DOI
出版ステータスPublished - 2005 11月
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学
  • 細胞生物学

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