Production of inbred and hybrid transgenic mice carrying large (>200 kb) foreign DNA fragments by intracytoplasmic sperm injection

Tomoharu Osada, Atsushi Toyoda, Stefan Moisyadi, Hidenori Akutsu, Masahira Hattori, Yoshiyuio Sakaki, Ryuzo Yanagimachi

研究成果: Article

27 引用 (Scopus)

抜粋

We have developed a mouse transgenesis technique that facilitates the insertion of large (∼200 kilo base pairs) DNA fragments into host genomes of both inbred and hybrid mice. Six inbred and three hybrid transgenic mice carrying a single bacterial artificial chromosome (BAC) clone with genes located in the Down syndrome critical region of human chromosome 21 were produced using this technology.

元の言語English
ページ(範囲)329-335
ページ数7
ジャーナルMolecular Reproduction and Development
72
発行部数3
DOI
出版物ステータスPublished - 2005 11
外部発表Yes

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ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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