Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes

J. G. Metz*, P. Roessler, D. Facciotti, C. Levering, F. Dittrich, M. Lassner, R. Valentine, K. Lardizabal, F. Domergue, A. Yamada, Kazunaga Yazawa, V. Knauf, J. Browse

*この研究の対応する著者

研究成果: Article査読

531 被引用数 (Scopus)

抄録

Polyunsaturated fatty acids (PUFAs) are essential membrane components in higher eukaryotes and are the precursors of many lipid-derived signaling molecules. Here, pathways for PUFA synthesis are described that do not require desaturation and elongation of saturated fatty acids. These pathways are catalyzed by polyketide synthases (PKSs) that are distinct from previously recognized PKSs in both structure and mechanism. Generation of cis double bonds probably involves position-specific isomerases; such enzymes might be useful in the production of new families of antibiotics. It is likely that PUFA synthesis in cold marine ecosystems is accomplished in part by these PKS enzymes.

本文言語English
ページ(範囲)290-293
ページ数4
ジャーナルScience
293
5528
DOI
出版ステータスPublished - 2001 7月 13
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ASJC Scopus subject areas

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