Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes

J. G. Metz, P. Roessler, D. Facciotti, C. Levering, F. Dittrich, M. Lassner, R. Valentine, K. Lardizabal, F. Domergue, A. Yamada, Kazunaga Yazawa, V. Knauf, J. Browse

研究成果: Article

417 引用 (Scopus)

抄録

Polyunsaturated fatty acids (PUFAs) are essential membrane components in higher eukaryotes and are the precursors of many lipid-derived signaling molecules. Here, pathways for PUFA synthesis are described that do not require desaturation and elongation of saturated fatty acids. These pathways are catalyzed by polyketide synthases (PKSs) that are distinct from previously recognized PKSs in both structure and mechanism. Generation of cis double bonds probably involves position-specific isomerases; such enzymes might be useful in the production of new families of antibiotics. It is likely that PUFA synthesis in cold marine ecosystems is accomplished in part by these PKS enzymes.

元の言語English
ページ(範囲)290-293
ページ数4
ジャーナルScience
293
発行部数5528
DOI
出版物ステータスPublished - 2001 7 13
外部発表Yes

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Polyketide Synthases
Fatty Acid Synthases
Eukaryota
Unsaturated Fatty Acids
Isomerases
Enzymes
Ecosystem
Fatty Acids
Anti-Bacterial Agents
Lipids
Membranes

ASJC Scopus subject areas

  • General

これを引用

Metz, J. G., Roessler, P., Facciotti, D., Levering, C., Dittrich, F., Lassner, M., ... Browse, J. (2001). Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. Science, 293(5528), 290-293. https://doi.org/10.1126/science.1059593

Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. / Metz, J. G.; Roessler, P.; Facciotti, D.; Levering, C.; Dittrich, F.; Lassner, M.; Valentine, R.; Lardizabal, K.; Domergue, F.; Yamada, A.; Yazawa, Kazunaga; Knauf, V.; Browse, J.

:: Science, 巻 293, 番号 5528, 13.07.2001, p. 290-293.

研究成果: Article

Metz, JG, Roessler, P, Facciotti, D, Levering, C, Dittrich, F, Lassner, M, Valentine, R, Lardizabal, K, Domergue, F, Yamada, A, Yazawa, K, Knauf, V & Browse, J 2001, 'Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes', Science, 巻. 293, 番号 5528, pp. 290-293. https://doi.org/10.1126/science.1059593
Metz JG, Roessler P, Facciotti D, Levering C, Dittrich F, Lassner M その他. Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. Science. 2001 7 13;293(5528):290-293. https://doi.org/10.1126/science.1059593
Metz, J. G. ; Roessler, P. ; Facciotti, D. ; Levering, C. ; Dittrich, F. ; Lassner, M. ; Valentine, R. ; Lardizabal, K. ; Domergue, F. ; Yamada, A. ; Yazawa, Kazunaga ; Knauf, V. ; Browse, J. / Production of polyunsaturated fatty acids by potyketide synthases in both prokaryotes and eukaryotes. :: Science. 2001 ; 巻 293, 番号 5528. pp. 290-293.
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