Productivity and bioactivity of enokipodins A–D of Flammulina rossica and Flammulina velutipes

Akiko Tabuchi, Emi Fukushima-Sakuno*, Kumiko Osaki-Oka, Yushi Futamura, Takayuki Motoyama, Hiroyuki Osada, Noemia Kazue Ishikawa, Eiji Nagasawa, Keisuke Tokimoto

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Enokipodins are antimicrobial sesquiterpenes produced by Flammulina velutipes in a mycelial culture medium. To date, enokipodin production has not been reported in other members of the genus Flammulina. Hence, in this study, the production of enokipodins A, B, C, and D by F. velutipes and F. rossica was investigated. Some strains of F. rossica were confirmed to produce at least one of the four enokipodins in the culture medium. However, some strains of F. velutipes did not produce any of the enokipodins. In an antibacterial assay using liquid medium, enokipodin B showed the strongest growth inhibitory activity against Bacillus subtilis among the four types of enokipodins. Enokipodin B inhibited the spore germination of some plant pathogenic fungi. Enokipodins B and D exerted moderate anti-proliferative activity against some cancer cell lines, and enokipodins A and C inhibited the proliferation of the malarial parasite, Plasmodium falciparum.

本文言語English
ページ(範囲)876-886
ページ数11
ジャーナルBioscience, Biotechnology and Biochemistry
84
5
DOI
出版ステータスPublished - 2020 5月 3
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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