Background: Based on the experiences of the pneumatically driven total artificial heart (TAH), the development of an implantable TAH using undulation pumps started in 1992. Methods: The undulation pump is a small-sized, continuous flow displacement-type blood pump, and the undulation pump total artificial heart (UPTAH) is a unique implantable TAH using undulation pumps. To date, 25 animal experiments were performed using adult female goats weighing 40.0-79.2 kg. The left pump was driven with completely pulsatile flow mode. The right pump was driven with pulsatile flow on continuous flow mode, in which each pump had systolic high flow and diastolic low flow phases. Results: In spite of the limitation of the chest cavity in goats, the UPTAH could be implanted into the chest in all cases. Using the left atrial pressure control to automatically control the left pump and thereby maintain left atrial pressure below 20 mmHg, ordinarily at around 8 mmHg, 31 days' survival could be obtained in a goat. With the 1/R control, 46 days' survival could be obtained in a goat. In all cases, major thrombus was not found inside the pumps. However, temperature rise in the left motor was a problem. Discussion: More than 1 month's survival could be obtained with UPTAH. How to prevent the temperature rise in motor is the next important subject for future study.
|ジャーナル||Journal of Congestive Heart Failure and Circulatory Support|
|出版ステータス||Published - 2000|
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