Protein large-scale motions revealed by quantum beams: A new era in understanding protein dynamics

Naoki Yamamoto*, Rintaro Inoue, Ikuo Kurisaki, Tatsuhito Matsuo, Yuki Hishikawa, Wenyang Zhao, Hiroshi Sekiguchi


研究成果: Article査読


Biological systems function by constantly changing their hierarchical or inter-hierarchical interactions among molecules, cells, and individuals. To visualize these dynamics, it is effective to approach them using penetrating quantum beams such as X-rays and neutron beams. Furthermore, the interpretation of the experimental results can be deepened by theoretical and computational techniques such as molecular dynamics simulations, which also complement phenomena hard to trace by experiments. For these issues, we have a symposium at the 60th Annual Meeting of the Biophysical Society of Japan held in September 2022 inviting 7 speakers, which is organized by Sekiguchi and Yamamoto. At the symposium, we will review recent advances in quantum beam techniques for biophysical research, mainly focusing on protein large conformational changes using X-ray (Sekiguchi, Yamamoto), neutron scattering (Matsuo), or a combination of both techniques (Inoue). We will also show theoretical studies that interpret or support experimental results (Kurisaki, Zhao) and a combination of experimental and theoretical studies (Hishikawa).

ジャーナルBiophysics and physicobiology
出版ステータスPublished - 2022

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 生理学
  • 生化学、遺伝学、分子生物学(その他)


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