Proton mediated control of biochemical reactions with bioelectronic pH modulation

Yingxin Deng, Takeo Miyake*, Scott Keene, Erik E. Josberger, Marco Rolandi

*この研究の対応する著者

研究成果: Article査読

18 被引用数 (Scopus)

抄録

In Nature, protons (H+) can mediate metabolic process through enzymatic reactions. Examples include glucose oxidation with glucose dehydrogenase to regulate blood glucose level, alcohol dissolution into carboxylic acid through alcohol dehydrogenase, and voltage-regulated H+ channels activating bioluminescence in firefly and jellyfish. Artificial devices that control H+ currents and H+ concentration (pH) are able to actively influence biochemical processes. Here, we demonstrate a biotransducer that monitors and actively regulates pH-responsive enzymatic reactions by monitoring and controlling the flow of H+ between PdHx contacts and solution. The present transducer records bistable pH modulation from an "enzymatic flip-flop" circuit that comprises glucose dehydrogenase and alcohol dehydrogenase. The transducer also controls bioluminescence from firefly luciferase by affecting solution pH.

本文言語English
論文番号24080
ジャーナルScientific reports
6
DOI
出版ステータスPublished - 2016 4月 7
外部発表はい

ASJC Scopus subject areas

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