Proton mediated control of biochemical reactions with bioelectronic pH modulation

Yingxin Deng, Takeo Miyake, Scott Keene, Erik E. Josberger, Marco Rolandi

研究成果: Article

14 引用 (Scopus)


In Nature, protons (H+) can mediate metabolic process through enzymatic reactions. Examples include glucose oxidation with glucose dehydrogenase to regulate blood glucose level, alcohol dissolution into carboxylic acid through alcohol dehydrogenase, and voltage-regulated H+ channels activating bioluminescence in firefly and jellyfish. Artificial devices that control H+ currents and H+ concentration (pH) are able to actively influence biochemical processes. Here, we demonstrate a biotransducer that monitors and actively regulates pH-responsive enzymatic reactions by monitoring and controlling the flow of H+ between PdHx contacts and solution. The present transducer records bistable pH modulation from an "enzymatic flip-flop" circuit that comprises glucose dehydrogenase and alcohol dehydrogenase. The transducer also controls bioluminescence from firefly luciferase by affecting solution pH.

ジャーナルScientific reports
出版物ステータスPublished - 2016 4 7

ASJC Scopus subject areas

  • General

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