Pseudotheonamides, serine protease inhibitors from the marine sponge Theonella swinhoei

Yoichi Nakao, Akito Masuda, Shigeki Matsunaga, Nobuhiro Fusetani*

*この研究の対応する著者

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Six new peptides with serine protease inhibitory activity have been isolated from the marine sponge Theonella swinhoei. Their structures including absolute stereochemistry were unambiguously established by interpretation of spectral data and chemical degradation. Pseudotheonamides A1 (1), A2 (2), and B2 (3) are linear pentapeptides embracing the rare piperazinone and piperidinoiminoimidazolone ring systems. Pseudotheonamide C (4) contains v-Tyr (vinylogous tyrosine) instead of a piperazinone ring. Pseudotheonamide D (5) is a tetrapeptide which lacks a C-terminal k-Arg (α- ketohomoarginine) unit. Dihydrocyclotheonamide A (6) is a reduction product of the known cyclotheonamide A (7).

本文言語English
ページ(範囲)2425-2431
ページ数7
ジャーナルJournal of the American Chemical Society
121
11
DOI
出版ステータスPublished - 1999 3月 24
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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