Pulse wave velocity is associated with increased plasma oxLDL in ageing but not with FGF21 and habitual exercise

Shuen Yee Lee, Stephen F. Burns, Kenneth K.C. Ng, David J. Stensel, Liang Zhong, Frankie H.Y. Tan, Kar Ling Chia, Kai Deng Fam, Margaret M.C. Yap, Kwee Poo Yeo, Eric P.H. Yap, Chin Leong Lim*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21–adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age-and sex-matched healthy individuals were assigned to younger sedentary or active (18–36 years old, n = 20 each) and older sedentary or active (45–80 years old, n = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both p < 0.001) in older than younger adults, despite no difference in FGF21 concentration (p = 0.097) between age groups. PWV (p = 0.09) and oxLDL concentration (p = 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (p = 0.011). Adiponectin concentration did not differ by age (p = 0.642) or exercise habits (p = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults.

本文言語English
論文番号221
ジャーナルAntioxidants
9
3
DOI
出版ステータスPublished - 2020 3月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 分子生物学
  • 臨床生化学
  • 細胞生物学

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